CD1E
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Official Full Name
CD1e molecule -
Overview
This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes within Golgi compartments, endosomes, and lysosomes, and is cleaved into a stable soluble form. The soluble form is required for the intracellular processing of some glycolipids into a form that can be presented by other CD1 family members. Many alternatively spliced transcript variants encoding different isoforms have been described. Additional transcript variants have been found; however, their biological validity has not been determined. T-cell surface glycoprotein CD1e, membrane-associated?is aprotein?that in humans is encoded by the?CD1E?gene. -
Synonyms
CD1E;CD1e molecule;CD1e antigen , CD1E antigen, e polypeptide;T-cell surface glycoprotein CD1e, membrane-associated;CD_antigen=CD1e;CD1A;CD1e antigen;CD1E antigen, e polypeptide;Differentiation antigen CD1-alpha-3;hCD1e;Leukocyte differentiation antigen;R2;R2G1;sCD1e;T-cell surface glycoprotein CD1e, soluble;thymocyte antigen CD1E
Recombinant Proteins
- Human
- Rhesus macaque
- Guinea pig
- E.coli
- Mammalian Cells
- HEK293
- Human Cells
- His
- Non
- His&Fc&Avi
Involved Pathway
CD1E involved in several pathways and played different roles in them. We selected most pathways CD1E participated on our site, such as Hematopoietic cell lineage, which may be useful for your reference. Also, other proteins which involved in the same pathway with CD1E were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Hematopoietic cell lineage | CD22,HLA-DRB5,IL11,CD1B,CD3G,THPO,Il6ra,GP5,CD1D2,IL7R |
Protein Function
CD1E has several biochemical functions, for example, beta-2-microglobulin binding,endogenous lipid antigen binding,exogenous lipid antigen binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CD1E itself. We selected most functions CD1E had, and list some proteins which have the same functions with CD1E. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| lipopeptide binding | TLR6,CD1C,CD1d1,CD1B,CD1D,CD1D2,CD1A |
| exogenous lipid antigen binding | CD1D2,CD1A,CD1B,CD1D,CD1d1,CD1C |
| beta-2-microglobulin binding | CD1C,HFE,HLA-A,CD1D,HLA-E,CD1D2,H2-Q10,CD1B,FCGRT,CD1d1 |
| endogenous lipid antigen binding | CD1D,CD1d1,CD1C,CD1B,CD1A,CD1D2 |
Interacting Protein
CD1E has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CD1E here. Most of them are supplied by our site. Hope this information will be useful for your research of CD1E.
Resources
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References
- Wu, LY; Zhou, Y; et al. The effect of TNF-alpha, Fc gamma R and CD1 polymorphisms on Guillain-Barre syndrome risk: Evidences from a Meta-Analysis. JOURNAL OF NEUROIMMUNOLOGY 243:18-24(2012).
- Vlam, L; Cats, EA; et al. Multifocal motor neuropathy is not associated with genetic variation in PTPN22, BANK1, Blk, FCGR2B, CD1A/E, and TAG-1 genes. JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM 16:175-179(2011).
